ISX9

SKU: orb1306776

Description

ISX-9 (Isoxazole 9) is a neurogenesis inducer that functions by activating neuron-specific gene expression. This small molecule is widely used in neuroscience research, facilitating the study of neurogenesis and neuronal differentiation in both in vitro cell culture models and in vivo experimental systems.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 832115-62-5
• MW: 234.28
• Purity: >98%
• Formula: C₁₁ H₁₀ N₂ O₂ S
• SMILES: O=C(NC1CC1)c1cc(on1)-c1cccs1
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml).

Bioactivity

• In Vivo:
  In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.
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• In Vitro:
  In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.
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• Cell Research:
  Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, Calcium Channel, Ca2+ channels, Ca channels, Ca2+, CalciumChannel, bcatenin, Inhibitor, Mef2, NMDA, neuroD, inhibit, ISX9, ISX-9, ISX 9, Isoxazole 9, Isoxazole 9 (ISX-9), Isoxazole9, Isoxazole-9, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, βcatenin

Compound Identifiers

PubChem CID

19582717