Ispronicline

SKU: orb1700319

Description

Ispronicline (TC-1734) is a potent and selective partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR), exhibiting high affinity (Ki=11 nM). This small molecule is utilized in research exploring cognitive enhancement, neuroprotection, and antidepressant mechanisms, with applications in both in vitro binding studies and in vivo behavioral models.

Research Area

Neuroscience

Key Properties

• CAS Number: 252870-53-4
• MW: 234.34
• Purity: 99.16% (May vary between batches)
• Formula: C₁₄H₂₂N₂O
• SMILES: CN[C@@H](C)C\C=C\c1cncc(OC(C)C)c1
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.53 mM);DMSO:50 mg/mL (213.37 mM)

Bioactivity

• In Vivo:
  In rats, the subcutaneous administration of Ispronicline (10-20 mg/kg) leads to the induction of c-Fos expression in specific regions of the forebrain. The pharmacokinetics of Ispronicline, characterized by a half-life of 2 hours in rats, contrasts with the sustained enhancement of working memory, lasting from 18 hours to 2 days.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RJR-1734, α4β2 nAChR, TC 01734, TC1734, TC-1734, TC 1734, TC01734, TC-01734, AZD 3480, AZD3480, AZD-3480, Ispronicline

Compound Identifiers

PubChem CID

9824145