Isotrifoliin

SKU: orb1689949

Description

ISOQUERCITRIN

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 21637-25-2
• MW: 464.38
• Purity: 99.45%
• Formula: C₂₁H₂₀O₁₂
• SMILES: OC[C@@H](O)[C@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@H]1O
• Target: Reactive Oxygen Species
• Solubility: DMSO:125 mg/mL (269.18 mM)

Bioactivity

• In Vivo:
  In animal studies, both Isoquercitrin and quercetin administration resulted in reduced eosinophil counts in the bronchoalveolar lavage fluid (BALF), blood, and lung parenchyma. Isoquercitrin-treated mice uniquely exhibited decreased neutrophil counts in blood and lower IL-5 concentrations in lung homogenates. No significant changes were observed in mononuclear cell counts.
• In Vitro:
  Isoquercitrin occurs widely in plants.10 μM of Isoquercitrin of the seven compounds partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Isotrifoliin, Isoquercetin, ISOQUERCITRIN, Isoquercitroside, inhibit, Reactive Oxygen Species, ReactiveOxygenSpecies

Compound Identifiers

PubChem CID

5484006