Isotretinoin

SKU: orb1224995

Description

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain Y, pancreatic Y and more.

Key Properties

• CAS Number: 4759-48-2
• MW: 300.44
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₈O₂
• SMILES: CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C/C(O)=O
• Target: Retinoid Receptor
• Solubility: Ethanol: 1 mg/mL warmed (3.32 mM); DMSO: 60 mg/mL (199.7 mM)

Bioactivity

• In Vivo:
  Animal model: Male A/J mice, lung carcinogenesis model. Dosage: 1.3, 20.7, or 481 μg/L. Administration: Inhalation exposure, 45 min daily for 2 weeks. Result: Reduced the tumor multiplicity. Caused up-regulation of lung tissue nuclear retinoic acid receptors (RARs) relative to vehicle-exposed mice, RARα (3.9-fold vehicle), RARβ (3.3-fold), and RARγ (3.7-fold) at 20.7 μg/L. Animal model: Wistar rats, tooth extraction model. Dosage: 7.5 mg/kg. Administration: Oral gavage, daily for 30 days. Result: Accelerated the process of alveolar repair, significantly decreased serum calcium levels.
• In Vitro:
  Cell Viability Assay Cell line: HepG2. Concentration: 0.1, 0.5, 1, 5, 10, 20, and 40 μM Incubation time: 24, 48, 72, and 96 h. Result: Showed a significant reduction in cell viability (less than 30%) at 96 h for all doses. RT-PCR Cell line: HepG2. Concentration: 10 μM. Incubation time: 48 h. Result: Significantly reduced the expression of c-MYC mRNA by ~80%.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AGN 190013 | 13(Z)-Retinoic Acid | 13-cis-Vitamin A Acid

Quick Database Links

Gene Symbol

Retinoid Receptor