Isosorbide dinitrate

SKU: orb1223780

Description

A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. (In Vivo):Isosorbide dinitrate (3 mg/kg; intratracheal; for 13 days) improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction.Isosorbide dinitrate postconditioning exhibits a cardioprotective effect against rat myocardial ischemia-reperfusion injury in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87-33-2
• MW: 236.14
• Purity: >98% (HPLC)
• Formula: C₆H₈N₂O₈
• SMILES: O=[N+]([O-])O[C@H]1[C@@H](OC[C@H]2O[N+]([O-])=O)[C@@H]2OC1
• Target: NPR1
• Solubility: Soluble in Water

Bioactivity

• In Vivo:
  Animal model: 5–6 weeks old male juvenile Sprague-Dawley rats (200–250 g). Dosage: 3 mg/kg. Administration: Intratracheal; for 13 days following coronary ligation. Result: Reduced MI size and alleviated left and right ventricular remodeling following MI.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 80038

Quick Database Links

Gene Symbol

NPR1