Isosilybin B

SKU: orb1684500

Description

Isosilybin B

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 142796-22-3
• MW: 482.44
• Purity: 100.00% (May vary between batches)
• Formula: C₂₅H₂₂O₁₀
• SMILES: C(O)[C@H]1[C@@H](OC=2C(O1)=CC(=CC2)[C@H]3OC=4C(C(=O)[C@@H]3O)=C(O)C=C(O)C4)C5=CC(OC)=C(O)C=C5
• Target: Apoptosis|||Androgen Receptor

Bioactivity

• In Vivo:
  Isosilybin B (50 and 100 mg/kg body weight; oral) effectively inhibits the growth of advanced human PCA DU145 xenografts. Immunohistochemical analyses revealed that Isosilybin B inhibit tumor angiogenesis biomarkers (CD31 and nestin) and signaling molecules regulating angiogenesis (VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α±) without adversely affecting the vessel-count in normal tissues (liver, lung, and kidney) of tumor-bearing mice.
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• In Vitro:
  Isosilybin B also inhibited the microvessel sprouting from mouse dorsal aortas ex vivo, and the VEGF-induced cell proliferation, capillary-like tube formation, and invasiveness of human umbilical vein endothelial cells (HUVEC) in vitro. Further studies in HUVEC showed that these diastereoisomers target cell cycle, apoptosis, and VEGF-induced signaling cascade. Three-dimensional growth assay as well as co-culture invasion and in vitro angiogenesis studies (with HUVEC and DU145 cells) suggested the differential effectiveness of the diastereoisomers toward PCA and endothelial cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Androgen Receptor, AndrogenReceptor, Apoptosis, Isosilybin B, Mdm2, PI3K

Compound Identifiers

PubChem CID

10885340