Isorubrofusarin-6-O-β-gentiobioside

SKU: orb1297322

Description

This small molecule, isolated from Cassia obtusifolia seeds, is a dual inhibitor of acetylcholinesterase (AChE) and β-secretase (BACE1). It serves as a key research tool for in vitro studies investigating potential therapeutic pathways for Alzheimer's disease.

Research Area

Neuroscience

Key Properties

• CAS Number: 200127-93-1
• MW: 596.53
• Purity: 99.89% (May vary between batches)
• Formula: C₂₇H₃₂O₁₅
• SMILES: O(C=1C2=C3C(=C(O)C=C2C=C(OC)C1)C(=O)C=C(C)O3)[C@@H]4O[C@H](CO[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O
• Target: AChR,BACE
• Solubility: DMSO:3 mg/mL (5.03 mM)

Bioactivity

• In Vitro:
  The SARs results emphasized the importance of gentiobiosyl moiety in Isorubrofusarin-6-O-β-gentiobioside for AChE inhibition, whereas the presence of hydroxyl group at C-8 and the glucosyl moiety at the C-6 position in the Isorubrofusarin-6-O-β-gentiobioside appeared to largely determine BACE1 inhibition.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BACE, BACE1, AChR, Isorubrofusarin 10-gentiobioside, Isorubrofusarin-6-O-beta-gentiobioside, Isorubrofusarin-6-O-b-gentiobioside, Isorubrofusarin-6-O-β-gentiobioside

Compound Identifiers

PubChem CID

10627344