Isorhamnetin-3-O-glucoside

SKU: orb1301263

Description

Isorhamnetin-3-O-glucoside is a bioactive flavonoid that potently inhibits rat intestinal alpha-glucosidase and rat lens aldose reductase (IC₅₀ = 1.4 µM), reducing sorbitol accumulation. These in vitro activities highlight its potential as a candidate for research into diabetes management and the prevention of diabetic complications.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 5041-82-7
• MW: 478.40
• Purity: 99.81% (May vary between batches)
• Formula: C₂₂H₂₂O₁₂
• SMILES: COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
• Target: PERK,Others,Lipase,Akt,PI3K,ERK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5.00 mg/mL (10.45 mM);DMSO:250.00 mg/mL (522.58 mM)

Bioactivity

• In Vitro:
  The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. METHODS AND RESULTS:The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. CONCLUSIONS:These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Isorhamnetin-3-O-b-D-Glucoside, Isorhamnetin-3-O-beta-D-Glucoside, Isorhamnetin3Oglucoside, Isorhamnetin-3-O-glucoside, Isorhamnetin 3 O glucoside, Isorhamnetin-3-O-β-D-Glucoside, IL Receptor, Inhibitor, RLAR

Compound Identifiers

PubChem CID

5318645