Isoliquiritin apioside

SKU: orb1220302

Description

Isoliquiritin apioside isolated from Glycyrrhizae radix rhizome significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. Isoliquiritin apioside has marked potential to combat oxidative stress-induced genotoxicity.

Key Properties

• CAS Number: 120926-46-7
• MW: 550.5
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₀O₁₃
• SMILES: C1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC=C(C=C3)/C=C/C(=O)C4=C(C=C(C=C4)O)O)CO)O)O)O)(CO)O
• Target: NF-κB
• Solubility: In Vitro: DMSO : 25 mg/mL (45.41 mM)

Bioactivity

• In Vitro:
  Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB