Isolinderalactone

SKU: orb1299116

Description

Isolinderalactone is a sesquiterpene lactone with demonstrated anti-inflammatory and anticancer properties. It acts as a moderate iNOS inhibitor (IC50 = 0.30 µM) and has shown research utility in both in vitro cell-based assays and in vivo models for studying related pathways.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 957-66-4
• MW: 244.29
• Purity: 99.62% (May vary between batches)
• Formula: C₁₅H₁₆O₃
• SMILES: [H][C@@]12OC(=O)C(=C)[C@]1([H])[C@](C)(Cc1occ(C)c21)C=C
• Target: Bcl-2 Family,NOS,VEGFR,NF-κB,Apoptosis,Caspase,STAT,Survivin,IAP
• Solubility: DMSO:22.5 mg/mL (92.1 mM);10% DMSO+90% Corn Oil:2 mg/mL (8.19 mM)

Bioactivity

• Target IC50:
  iNOS:0.30 uM
• In Vitro:
  Isolinderalactone induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcl-2 Family, Inhibitor, IAP, iNOS, inhibit, Isolinderalactone, Vascular endothelial growth factor receptor, VEGFR, Survivin, STAT3

Compound Identifiers

PubChem CID

5318587