Isoforskolin

SKU: orb1297414

Description

Isoforskolin, a compound derived from Coleus forskohlii, suppresses the release of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 in human mononuclear leukocytes. This activity supports its research application in studying inflammatory conditions such as Lyme arthritis, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 64657-21-2
• MW: 410.50
• Purity: 99.87% (May vary between batches)
• Formula: C₂₂H₃₄O₇
• SMILES: [H][C@@]12[C@H](OC(C)=O)[C@H](O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
• Target: TNF,Interleukin,IL Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.00 mg/mL (2.44 mM);DMSO:2.10 mg/mL (5.12 mM)

Bioactivity

• In Vivo:
  Isoforskolin downregulats the transcription and expression of TNF-α and IL-6 induced by rBmpA in mice. Isoforskolin inhibits the symptoms of experimental Lyme arthritis.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Coleonol B, IL Receptor, ILReceptor, IL-6, IL-8, IL-1β, Isoforskolin, TNF-α

Compound Identifiers

PubChem CID

9549169