Isoescin IB

SKU: orb1297328

Description

Isoescin IB

Key Properties

• CAS Number: 219944-46-4
• MW: 1131.26
• Purity: 99.42%
• Formula: C₅₅H₈₆O₂₄
• SMILES: [H][C@@]1(O[C@H]2[C@H](O)[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@]([H])(O[C@H]3CC[C@@]4(C)[C@@]([H])(CC[C@]5(C)[C@]4([H])CC=C4[C@]6([H])CC(C)(C)[C@@H](OC(=O)C(\C)=C/C)[C@H](O)[C@]6(COC(C)=O)[C@H](O)C[C@@]54C)[C@@]3(C)CO)O[C@@H]2C(O)=O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
• Target: Others
• Solubility: DMSO:100 mg/mL (88.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (3.54 mM)

Bioactivity

• In Vivo:
  Five groups of Wistar rats ( = per group) were treated with either an intravenous (IV) dose (2.7 mg/kg) of sodium escinate (corresponding to 0. mg/kg of Escin IB and 0. mg/kg of Isoescin IB), an IV dose (0. mg/kg) and an oral dose ( mg/kg) of pure Escin IB or Isoescin IB the administration of sodium escinate, which contain the two isomers, gave rise to higher terminal phase half-life (t1/2) and mean residence time (MRT) Values for both Escin IB and Isoescin IB compared to the corresponding compounds administered alone the absorption of Escin IB and Isoescin IB was very poor, wit the oral bioavailability (F) Values of < % observed for both compounds the two compounds were found to isomerize in vivo wherei the conversion of Escin IB to Isoescin IB was much easier than that of Isoescin IB to Escin I.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Isoescin IB, Inhibitor, Escin, Escin IB

Compound Identifiers

PubChem CID

6476033