Isodeoxyelephantopin

SKU: orb1297530

Description

Isodeoxyelephantopin is a bioactive sesquiterpene lactone with demonstrated anti-proliferative activity against multiple cancer cell lines in vitro. Research indicates its potential application in oncology studies, particularly for investigating mechanisms of apoptosis and tumor growth inhibition.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 38927-54-7
• MW: 344.36
• Purity: 99.88% (May vary between batches)
• Formula: C₁₉H₂₀O₆
• SMILES: [H][C@]12C\C(C)=C/[C@@]3([H])OC(=O)C(=C)[C@]3([H])[C@H](CC(=C1)C(=O)O2)OC(=O)C(C)=C
• Target: Autophagy,Reactive Oxygen Species,ROS,NF-κB
• Solubility: DMSO:55 mg/mL (159.72 mM)

Bioactivity

• In Vitro:
  Isodeoxyelephantopin inhibits the growth of A549 and T47D cells in a dose-dependent and time-dependent manner with IC50 values of 10.46 and 1.3 μg/mL, respectively. Heterodeoxyelephantin showed no significant toxicity to normal lymphocytes. Heterodeoxyelephinin-induced cell death is associated with activated caspase-3 expression, followed by cell cycle stagnation in G2/M phase

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, ROS, Isodeoxyelephantopin, inhibit, NF-kB, NF-κB, NFκB, NFkB, Nuclear factor-kappaB, Nuclear factor-κB, Inhibitor, IL receptor, Autophagy

Compound Identifiers

PubChem CID

92982622