Isobavachromene

SKU: orb1297329

Description

Isobavachromene is a bioactive small molecule that inhibits both NADH-Ubiquinone oxidoreductase (Complex I) and ornithine decarboxylase. This dual inhibitory activity underlies its observed antifungal properties, making it a useful research tool for studying mitochondrial function, polyamine biosynthesis, and antifungal mechanisms in vitro.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 52801-22-6
• MW: 322.35
• Purity: 99.18% (May vary between batches)
• Formula: C₂₀H₁₈O₄
• SMILES: CC1(C)Oc2ccc(C(=O)\C=C\c3ccc(O)cc3)c(O)c2C=C1
• Target: Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.2 mM);DMSO:25 mg/mL (77.56 mM)

Bioactivity

• In Vitro:
  Estrogenic activities of ethanol extract and its active components from Psoralea corylifolia L. were studied using various in vitro assays. The main components from ethanol extract were analyzed to be bakuchiol, psoralen, isobavachalcone, Isobavachromene, and bavachinin. In a fractionation procedure, hexane and chloroform fractions showed estrogenic activity in yeast transactivation assay and E-screen assay. In yeast transactivation assay, ethanol extract, hexane, and chloroform fractions showed significantly higher activities at a concentration of 1.0 ng/ml, and bakuchiol at the concentration of 10(-6) M was showed the highest activity, especially, which was higher than genistein at the same concentration
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Estrogen Receptor/ERR, inhibit, mutans, Isobavachromene, Bacterial, BACE, Antibacterial, ornithine decarboxylase, Streptococcus

Compound Identifiers

PubChem CID

5889042