Isobavachalcone

SKU: orb1225713

Description

Isobavachalcone (Corylifolinin, Isobacachalcone) is a chalcone constituent of Angelica keiskei that can induce apoptosis in several cancer cells, also shows activity against multidrug-resistant (MDR) Gram-negative bacterial isolates; significantly reduces pro-caspase-3 and pro-caspase-9, and subsequently increases the level of cleaved caspase-3 and cleaved caspase-9 in neuroblastoma cell lines also exhibiting deletions of the major efflux pump components (AcrAB, TolC).

Key Properties

• CAS Number: 20784-50-3
• MW: 324.3704
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₀O₄
• SMILES: O=C(C1=CC=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2
• Target: Flavonoids
• Solubility: DMSO: 11 mg/mL

Bioactivity

• In Vivo:
  Animal model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g). Dosage: 20 mg/kg. Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours. Result: Increased in blood glucose levels.
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• In Vitro:
  Cell Proliferation Assay Cell line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells. Concentration: 6.0-48.0 μM Incubation time: 72 hours. Result: Inhibited the proliferation of human cancer cells. Western blot analysis. Cell line: OVCAR-8 or PC3 cells. Concentration: 0 μM, 6 μM, 12 μM, and 18 μM. Incubation time: 6 hours. Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner. Apoptosis Analysis Cell line: OVCAR-8 cells and PC3 cells. Concentration: 0 μM, 6 μM, 12 μM, and 18 μM. Incubation time: 72 hours. Result: Led to dose dependent increase of apoptosis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Corylifolinin | Isobacachalcone

Quick Database Links

Gene Symbol

Flavonoids