Isobarbaloin

SKU: orb1310868

Description

Isobarbaloin

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 5133-19-7
• MW: 418.39
• Purity: 100.00%
• Formula: C₂₁H₂₂O₉
• SMILES: O=C1C2=C(C=CC=C2O)[C@H]([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C4=CC(CO)=CC(O)=C14
• Target: Tyrosinase
• Solubility: H2O:1 mg/mL (2.39 mM);DMSO:83 mg/mL (198.38 mM);Ethanol:2 mg/mL (4.78 mM)

Bioactivity

• In Vivo:
  In the MCF-7 cell line, Aloin diminishes the proportion of cells in mitosis by inducing apoptosis, suppresses the expression of topoisomerase IIα, and downregulates cyclin B1 protein expression. In HeLaS3 cells, Aloin exhibits significant antiproliferative effects at physiological concentration (IC50=97 μM), leading to cell cycle arrest in the S phase and a marked increase in apoptosis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aloin, Aloin-A, Barbaloin-A, Isobarbaloin, tyrosinase

Compound Identifiers

PubChem CID

12305761