Isoallolithocholic acid

SKU: orb1693659

Description

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a secondary bile acid metabolite that functions as a T-cell immunomodulator with demonstrated anti-inflammatory properties. It is utilized in research to investigate immune homeostasis, inflammation, and bile acid signaling in both cellular and animal models.

Key Properties

• CAS Number: 2276-93-9
• MW: 376.57
• Purity: 99.98% (May vary between batches)
• Formula: C₂₄H₄₀O₃
• SMILES: [H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C
• Target: Others
• Solubility: DMF:1 mg/mL (2.66 mM);DMF:PBS (pH 7.2) (1:3):0.25 mg/mL (0.66 mM)

Bioactivity

• In Vivo:
  Isoallolithocholic acid (0.03%; in the diet; 7 days; Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice) was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to the control diet in combination with 0.3% (w/w) 3-oxo-lithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells. Enhancing Treg cells in B6 mice.
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• In Vitro:
  Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by approximately 50% without affecting RORγt expression. It does not impact Th1 or Th2 cell differentiation, and its regulatory effect on Tregs is cell-type specific. Isoallolithocholic acid-dependent enhancement of FoxP3 expression requires mitoROS.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isoallolithocholic acid, Alloisolithocholic Acid, AILCA, 3b-Hydroxy-5a-cholanic acid, 3beta-Hydroxy-5alpha-cholanic acid, 3β-Hydroxy-5α-cholanic acid

Compound Identifiers

PubChem CID

94228