ISM7594

SKU: orb3136053

Description

ISM7594 is an orally active FGFR2/3 inhibitor demonstrating broad-spectrum antiproliferative capabilities in cancer cell lines with FGFR2 or FGFR3 alterations, such as amplification, fusion, and mutation (e.g., BaF3-TEL-FGFR2-V564F with an IC50 of 0.067 nM, BaF3-TEL-FGFR2-V564I with an IC50 of 2 nM). It inhibits tumor growth in a dose-dependent manner and is suitable for research on advanced solid tumors with FGFR2/3 abnormalities.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 3025799-76-9
• MW: 540.52
• Formula: C₂₉H₂₂F₂N₆O₃
• SMILES: O=C(N)C1=C2C=C(C=NN2C(C=3C=CC(=CC3)NC(=O)C(F)=C)=C1C4=CC=C(OC5=NC=CC(=N5)C)C(F)=C4)C
• Target: FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FGFR