Islatravir

SKU: orb1308032

Description

Islatravir (MK-8591) is a potent nucleoside reverse transcriptase inhibitor effective against HIV-1, including resistant strains like M184V and MDR variants. It is a key research compound for investigating antiviral mechanisms and therapeutic strategies in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 865363-93-5
• MW: 293.25
• Purity: 98.77% (May vary between batches)
• Formula: C₁₂H₁₂FN₅O₃
• SMILES: Nc1nc(F)nc2n(cnc12)[C@H]1C[C@H](O)[C@@](CO)(O1)C#C
• Target: HIV Protease,Reverse Transcriptase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.64 mM);DMSO:100 mg/mL (341.01 mM);H2O:3 mg/mL (10.23 mM)

Bioactivity

• Target IC50:
  HIV-1 (M184V):3.1 nM (EC50)|HIV-1 (WT):0.068 nM (EC50)|HIV-1 (MDR):0.15 nM (EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reverse Transcriptase, ReverseTranscriptase, inhibit, Islatravir, Inhibitor, MK8591, MK-8591, MK 8591, Human immunodeficiency virus, HIV, HIV Protease, HIVProtease, HIV-1 WT, HIV-1, HIV-1 M184V, HIV-1 MDR

Compound Identifiers

PubChem CID

6483431