Isatin

SKU: orb1221661

Description

Isatin, also called Tribulin, is a MAO-B and guanylate cyclase inhibitor found in Istasis, Calanthe and Courouptia. It prevents TNBS-induced increases in pro-inflammatory cytokines and protects agains colitis-induced injuries. Derivatives may inhibit cancer cell growth.(In Vitro):In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis.(In Vivo):A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations.

Key Properties

• CAS Number: 91-56-5
• MW: 147.13
• Purity: >98% (HPLC)
• Formula: C₈H₅NO₂
• SMILES: C1=CC=C2C(=C1)C(=O)C(=O)N2
• Target: Antioxidant
• Solubility: In Vitro: DMSO : 100 mg/mL (679.67 mM)

Bioactivity

• In Vivo:
  A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations.
• In Vitro:
  In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isatin | 2,3-Dioxo-2,3-dihydroindole | Isatic acid lactam | Isotin

Quick Database Links

Gene Symbol

Antioxidant