IS20

SKU: orb3173056

Description

IS20 is an agonist of prokineticin receptor 1 (PKR1). It reduces Doxorubicin-induced apoptosis and ROS production by activating the Akt or MAPK pathways. In mouse models, IS20 protects the heart from cardiovascular toxicity caused by Doxorubicin, improving survival rates and cardiac function. It does not alter the cytotoxicity and anti-tumor effects of acute Doxorubicin treatment on breast cancer cells and the MDA-MB-231 xenograft mouse model. IS20 is applicable in cancer research.

Key Properties

• CAS Number: 324561-95-7
• MW: 387.44
• Formula: C₂₃H₂₁N₃O₃
• SMILES: O=C(NC(=CC1=CC=C(OC)C=C1)C(=O)NCC=2C=NC=CC2)C=3C=CC=CC3
• Target: p38 MAPK,Apoptosis,ROS,Akt,GRK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK,Apoptosis,ROS,Akt,GRK