Ironomycin

SKU: orb3174198

Description

Ironomycin is a derivative of Salinomycin. It exhibits selective inhibitory activity against mantle cell lymphoma (MCL) cells. Ironomycin halts the cell cycle and induces apoptosis and ferroptosis. It also causes DNA double-strand breaks and activates the unfolded protein response (UPR), specifically accumulating the IRE1α signaling pathway. Combined use of Ironomycin and Ibrutinib shows a synergistic effect. Ironomycin is useful for MCL research.

Key Properties

• CAS Number: 1884647-72-6
• MW: 788.08
• Formula: C₄₅H₇₃NO₁₀
• SMILES: N(CC#C)[C@H]1[C@]2(O[C@@]3(O[C@]([C@H](C([C@H]([C@H]([C@H](C)[C@@]4(O[C@@]([C@H](C(O)=O)CC)(CC[C@@H]4C)[H])[H])O)C)=O)CC)([C@@H](C)C[C@H]3C)[H])C=C1)O[C@@](C)(CC2)[C@@]5(O[C@@H](C)[C@](CC)(O)CC5)[H]
• Target: DNA/RNA Synthesis,CDK,IRE1,Ferroptosis,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis,CDK,IRE1,Ferroptosis,Apoptosis,Caspase