IRF1-IN-2

SKU: orb2814648

Description

IRF1-IN-2 is a selective small molecule inhibitor of Interferon Regulatory Factor 1 (IRF1) that disrupts its binding to the CASP1 promoter. This action inhibits pyroptosis and has demonstrated protective effects against radiation-induced skin damage in vivo, making it a valuable tool for studying cell death pathways and inflammatory injury models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 708245-32-3
• MW: 360.43
• Purity: 99.85%
• Formula: C₁₈H₂₀N₂O₄S
• SMILES: O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCC2)C=3C=CC=CC3OC
• Target: Pyroptosis,Caspase,PARP,IFNAR,Glutathione Peroxidase,Interleukin
• Solubility: DMSO:105 mg/mL (291.32 mM)

Bioactivity

• In Vivo:
  Methods: IRF1-IN-2 (100 μg/d, subcutaneous injection, irradiated every other day) was administered to mice with inflammatory skin lesions induced by 35 Gy radiation, and its effects were observed. Results: IRF1-IN-2 has a potential protective effect against inflammatory skin lesions induced by 35 Gy radiation in mice.
• In Vitro:
  Pretreatment of irradiated HaCaT cells, HELF and WS1 cells with IRF1-IN-2 (20 μM, 12 h) reduced the recruitment of IRF1 to the CASP1 promoter in HaCaT cells (20 Gy) and also attenuated IRF1 activation induced by NSP-10 plasmid transfection in HELF and WS1 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IRF1-IN2

Compound Identifiers

PubChem CID

1090685