IRBM-Z-2

SKU: orb3211372

Description

IRBM-Z-2 is a non-competitive, orally active inhibitor of the Zika virus (ZIKV) NS2B-NS3 protease, with IC50 values of 0.04 μM for the wild-type and 3.1 μM for the I156T mutant strain. It shows broad-spectrum antiviral potential against flaviviruses, with IC50 values of 2.1 μM for Dengue virus 2 (DENV2) and 0.09 μM for West Nile virus (WNV) NS2B-NS3 proteases. Additionally, IRBM-Z-1 inhibits Zika virus replication and alleviates virus-induced cytopathic effects, making it useful for studies related to ZIKV infection.

Key Properties

• CAS Number: 3014840-61-7
• MW: 469.42
• Formula: C₂₂H₁₈F₃N₇O₂
• SMILES: O=C([N-]C=1ON=[N+](C1)CC=2N=CC(=CC2)C3=C(N=CN=C3C)C)NC4=CC=CC(=C4)C(F)(F)F
• Target: Anti-infection,Virus Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Anti-infection,Virus Protease