Irbinitinib

SKU: orb1222982

Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

Key Properties

• CAS Number: 937263-43-9
• MW: 480.52
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₄N₈O₂
• SMILES: Cc1c(ccc(c1)Nc1ncnc2c1cc(cc2)NC1=NC(CO1)(C)C)Oc1cc2ncnn2cc1
• Target: GluR
• Solubility: DMSO : 50 mg/mL. 104.05 mM

Bioactivity

• In Vivo:
  Animal model: Female nude mice. Dosage: 200 mg/kg/d. Administration: PO, daily. Result: Exhibited anti-tumor activity and benefited survival.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARRY380 | ARRY 380 | ONT-380. Irbinitinib | Tucatinib

Quick Database Links

Gene Symbol

GluR