IRAK4-IN-4

SKU: orb1309540

Description

IRAK4-IN-4 is a potent dual-target inhibitor, demonstrating high activity against both cyclic GMP-AMP synthase (cGAS; IC50 = 2.1 nM) and interleukin-1 receptor-associated kinase 4 (IRAK4; IC50 = 2.8 nM). This compound is a valuable research tool for investigating innate immune signaling pathways, including the cGAS-STING and TLR/IL-1R axes, in both cellular and biochemical studies.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1850276-58-2
• MW: 340.37
• Purity: 99.52% (May vary between batches)
• Formula: C₂₂H₁₆N₂O₂
• SMILES: Cc1ccn2c(C(=O)C(=O)c3ccccc3)c(nc2c1)-c1ccccc1
• Target: cGAS,IRAK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.88 mM);DMSO:24 mg/mL (70.51 mM)

Bioactivity

• Target IC50:
  cGAS:2.1 nM (IC50)|IRAK4:2.8 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Interleukin-1 receptor associated kinase, IL-1R associated kinase, IRAK, IRAK4IN4, IRAK-4-IN-4, IRAK4-IN-4, IRAK4, IRAK4 IN 4, inhibit, cGAS, Cyclic GMP-AMP synthase, Cyclic GMP-AMP Synthase

Compound Identifiers

PubChem CID

145712357