IRAK4-IN-33

SKU: orb3174523

Description

IRAK4-IN-33 (Compound 22) is a selective and potent orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with an IC50 value of 0.36 nM. It effectively blocks pro-inflammatory signaling pathways mediated by IRAK4 and inhibits the release of TNFα and IFNα. Additionally, IRAK4-IN-33 demonstrates weak inhibition of the hERG channel (IC50 value greater than 30 μM). This compound is applicable in inflammation and immunology research, such as studies on rheumatoid arthritis.

Key Properties

• CAS Number: 2411497-72-6
• MW: 538.63
• Formula: C₂₇H₂₆N₁₀OS
• SMILES: N([C@@H](C#N)C)C=1C=C(C=2N3C(=CC2)C=C(C#N)C=N3)N=CC1C=4SC(=NN4)N5C[C@@]6([C@@H](NC(C)=O)[C@](C5)(CC6)[H])[H]
• Target: IRAK,TNF,IFNAR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IRAK,TNF,IFNAR