IRAK4-IN-33

SKU: orb3174523

Description

IRAK4-IN-33 (Compound 22) is a selective and potent orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with an IC50 value of 0.36 nM. It effectively blocks pro-inflammatory signaling pathways mediated by IRAK4 and inhibits the release of TNFα and IFNα. Additionally, IRAK4-IN-33 demonstrates weak inhibition of the hERG channel (IC50 value greater than 30 μM). This compound is applicable in inflammation and immunology research, such as studies on rheumatoid arthritis.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2411497-72-6
• MW: 538.63
• Formula: C₂₇H₂₆N₁₀OS
• SMILES: N([C@@H](C#N)C)C=1C=C(C=2N3C(=CC2)C=C(C#N)C=N3)N=CC1C=4SC(=NN4)N5C[C@@]6([C@@H](NC(C)=O)[C@](C5)(CC6)[H])[H]
• Target: IFNAR,TNF,IRAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IFNAR,TNF,IRAK