IRAK1/4/pan-FLT3 Kinase-IN-1

SKU: orb2814645

Description

Compound 31 is a highly potent, multi-kinase inhibitor targeting IRAK1, IRAK4, and FLT3 with sub-nanomolar to low nanomolar IC50 values. It demonstrates promising pharmacokinetics and, in preclinical acute myeloid leukemia models, shows survival extension comparable to Gilteritinib in both cellular and animal studies.

Research Area

Cardiovascular Research, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2760328-82-1
• MW: 399.46
• Formula: C₂₁H₂₆FN₅O₂
• SMILES: C(C)(C)(O)C1=CN2C(=CN=C2C=C1OC)C=3N=C(N[C@@H]4[C@@H](F)CCNC4)C=CC3
• Target: IRAK,FLT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166961659