IR415

SKU: orb1309542

Description

IR415 is a potent small molecule inhibitor of Hepatitis B virus (HBx) with a 2 nM binding affinity. It blocks HBx-mediated suppression of RNAi by restoring dicer endoribonuclease activity, thereby inhibiting HBV replication. This mechanism supports its utility in both in vitro and in vivo virology and antiviral research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 452967-14-5
• MW: 296.34
• Purity: 99.85% (May vary between batches)
• Formula: C₁₃H₁₄F₂N₄S
• SMILES: Fc1ccc(NC(=S)NCCCn2ccnc2)c(F)c1
• Target: HBV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.5 mM);DMSO:125 mg/mL (421.81 mM)

Bioactivity

• Target IC50:
  HBx:2 nM(Kd)
• In Vitro:
  IR415, at concentrations ranging from 50 to 200 μM, exhibits a dose-dependent inhibition of the Hepatitis B virus X protein (HBx), achieving its minimal effective concentration at 50 μM in the HepG2/GFP-shRNA line expressing HBx. HBx is identified as a suppressor of the host's defense mechanisms, specifically involved in the RNAi-based silencing of viral genes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HBV, HBX, hepatitis B, Hepatitis B virus, Hepatitis B virus X protein (HBx), HepG2, Inhibitor, inhibit, IR415, IR-415, IR415-HBx interaction, IR 415, cell, replication, VSR, virus

Compound Identifiers

PubChem CID

2824621