Ipivivint

SKU: orb3054173

Description

Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).

Key Properties

• CAS Number: 1481617-15-5
• MW: 464.5
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₁FN₈
• Solubility: DMSO : 3.33 mg/mL (7.17 mM; ultraphonic (<80°C); )

Bioactivity

• In Vivo:
  Animal model: Foxn1 mice. Dosage: 25 mg/kg. Administration: p.o. Result: Potently inhibited tumor SRSF6 phosphorylation.
• In Vitro:
  Western blot analysis. Cell line: SW480 cells. Concentration: 0.01~10 μM Incubation time: 1 hour. Result: Potently inhibited SRSF5/6 phosphorylation. Apoptosis Analysis Cell line: SW480 cells. Concentration: 0.01~10 μM Incubation time: 0.03 μM~3 μM Result: Induced apoptosis. RT-PCR Cell line: HEK-293T cells. Concentration: 0.3~3 μM Incubation time: 1 hour. Result: Inhibited Wnt/β-catenin signaling induced by Wnt3a. Immunofluorescence Cell line: SW480 cells. Concentration: 0.3~10 μM Incubation time: 6 hours. Result: Increased nuclear speckle enlargement.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only