IP7e

SKU: orb1305054

Description

IP7e

Research Area

Metabolism Research

Key Properties

• CAS Number: 500164-74-9
• MW: 390.43
• Purity: 99.86% (May vary between batches)
• Formula: C₂₃H₂₂N₂O₄
• SMILES: COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
• Target: NR4A,Others
• Solubility: DMSO:95 mg/mL (243.32 mM)

Bioactivity

• Target IC50:
  Nurr1:3.9 nM(EC50)
• In Vivo:
  IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

brain-penetrant, isoxazolo-pyridinone 7e, inhibit, IP7e, IP-7e, IP 7e, orally, Nurr1, NF-kB, Inhibitor

Compound Identifiers

PubChem CID

9908426