IOR-160

SKU: orb3136225

Description

IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2421119-78-8
• MW: 510.46
• Formula: C₂₃H₂₅F₃N₄O₆
• SMILES: O=C(O)C=1C=CC2=C(N=C(NCCCCCCCC(=O)NO)C=3C=CN=CC23)C1.O=C(O)C(F)(F)F
• Target: HDAC,Casein Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC,Casein Kinase