Insulin sensitizer C59

SKU: orb2646409

Description

C59 is an orally bioavailable small molecule insulin sensitizer that enhances cellular glucose uptake. It serves as a valuable research tool for investigating insulin signaling and GLUT4 translocation mechanisms in both in vitro and in vivo models of insulin resistance and diabetes. Insulin sensitizer C59 is supplied for research use only and is intended for laboratory research involving animal models. Biorbyt supplies these products exclusively to research institutions and commercial laboratories.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2761446-81-3
• MW: 325.23
• Purity: 99.98% (May vary between batches)
• Formula: C₁₆H₁₈Cl₂N₂O
• SMILES: O=C(NC1=NC=C(Cl)C(Cl)=C1)C23CC4CC(CC(C4)C2)C3
• Target: IGF-1R,PDE,Others

Bioactivity

• In Vivo:
  Lean mice were injected with either vehicle or Insulin sensitizer C59 before performing IPGTT. Like C3, Insulin sensitizer C59 injection resulted in improved glucose tolerance compared to vehicle. Oral administration of Insulin sensitizer C59 to DIO mice by providing them with HFD supplemented with Insulin sensitizer C59 for 2 weeks also resulted in significantly improved glucose tolerance, thus demonstrating oral availability of the compound. Injection of Insulin sensitizer C59 did not result in a lower body weight compared to control, suggesting that the improved glucose tolerance is not due to decreased weight gain.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

InsulinsensitizerC59

Compound Identifiers

PubChem CID

168431762