Insulin degludec

SKU: orb1940868

Description

Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM/L for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes. Insulin degludec is supplied for research use only and is intended for laboratory research involving animal models. Biorbyt supplies these products exclusively to research institutions and commercial laboratories.

Research Area

Metabolism Research

Key Properties

• CAS Number: 844439-96-9
• MW: ——
• Purity: >98% (HPLC)
• Formula: ——
• Target: Insulin Receptor
• Solubility: 0.1 M HCL : 50 mg/mL (ultrasonic and adjust pH to 2 with 0.1 M HCL)

Bioactivity

• In Vivo:
  Insulin degludec (5 U/kg; s. c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia. Animal model: Male Swiss mice with diabetes. Dosage: 5 U/kg. Administration: Subcutaneous injection; 5 U/kg once daily for 30 days. Result: Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
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• In Vitro:
  Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM. Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells. Western blot analysis. Cell line: HL-1 cardiomyocytes. Concentration: 200 nM. Incubation time: 0-60 min. Result: Decreased the level of Akt phosphorylation after 5 and 10 min treatment.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Insulin Receptor