inS3-54A18

SKU: orb1308190

Description

inS3-54A18 is a potent and selective STAT3 inhibitor with demonstrated anticancer activity. It has been utilized in both in vitro and in vivo research to study STAT3-driven oncogenesis and evaluate potential therapeutic strategies in various cancer models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 328998-53-4
• MW: 373.83
• Purity: 99.68% (May vary between batches)
• Formula: C₂₃H₁₆ClNO₂
• SMILES: Oc1ccc(cc1)N1C(=O)\C(=C/c2ccc(Cl)cc2)C=C1c1ccccc1
• Target: STAT
• Solubility: DMSO:150 mg/mL (401.25 mM)

Bioactivity

• In Vivo:
  inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model.
• In Vitro:
  inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, inS3 54A18, inS354A18, inS-3-54A18, inS3-54A18, STAT3, STAT

Compound Identifiers

PubChem CID

1920398