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INH14

SKU: orb1221045

Description

INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).

Images & Validation

Key Properties

CAS Number200134-22-1
MW240.3
Purity>98% (HPLC)
FormulaC15H16N2O
SMILESCCc1ccc(NC(=O)Nc2ccccc2)cc1
TargetIκB kinase (IKK)
SolubilityDMSO: 100 mg/mL (416.14 mM)

Bioactivity

In Vivo
INH14 (5 μg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice. Animal model: 8-week old, male, pathogen-free C57BL/6J mice. Dosage: 5 μg/g, one hour before Pam2CSK4 injection. Administration: i.p. for 2 hours. Result: Decreased TNFα production in mice.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 150.00
10 mg
$ 210.00
25 mg
$ 340.00
50 mg
$ 580.00
100 mg
$ 860.00