INDY

SKU: orb1308193

Description

INDY is a potent and selective ATP-competitive inhibitor of Dyrk1A and Dyrk1B kinases, exhibiting IC50 values of 0.24 μM and 0.23 μM, respectively. This small molecule is a valuable research tool for studying DYRK family kinase function in cellular models and investigating related pathways in neuroscience and cancer research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1169755-45-6
• MW: 235.3
• Purity: 98.15% (May vary between batches)
• Formula: C₁₂H₁₃NO₂S
• SMILES: CCN1\C(Sc2ccc(O)cc12)=C\C(C)=O
• Target: DYRK
• Solubility: DMSO:5 mg/mL (21.25 mM)

Bioactivity

• Target IC50:
  DYRK1B:0.23 μM|DYRK1A:(ki)0.18 μM|DYRK1A:0.24 μM
• In Vivo:
  In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.
• In Vitro:
  INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one, Dyrk1B, Dyrk1A, INDY

Compound Identifiers

PubChem CID

44136031