Indolicidin

SKU: orb1296658

Description

Indolicidin

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 140896-21-5
• MW: 1906.28
• Purity: 100.00%
• Formula: C₁₀₀H₁₃₂N₂₆O₁₃
• SMILES: CCC(C)C(N)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
• Target: Antibacterial
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  Indolicidin, a powerful antimicrobial peptide extracted from bovine neutrophil cytoplasmic granules, comprises 13 amino acids, including a notably high tryptophan content, with five tryptophan residues, and features a carboxamidated carboxylterminal arginine. This peptide, recognized for having the highest tryptophan level among proteins, also acts as a tridecapeptide amide exhibiting bactericidal activities rivaling those of prominent defensins and bactenecins in vitro. Its mechanism includes binding to surface lipopolysaccharide with high affinity, facilitating the permeabilization of Escherichia coli's outer membrane via the self-promoted uptake pathway, as evidenced by its interaction with 1-N-phenylnapthylamine. Furthermore, methyl esterification at Indolicidin's carboxyl terminus amplifies its effectiveness against both Gram-negative and Gram-positive bacteria, attributed to enhanced lipopolysaccharide binding and outer membrane permeabilization in Gram-negative bacteria, and pinpointing the cytoplasmic membrane as its action site through membrane permeabilization indicators in Escherichia coli.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Inhibitor, Indolicidin, inhibit

Compound Identifiers

PubChem CID

18628287