Indole-3-carbinol

SKU: orb1304812

Description

Indole-3-carbinol (I3C) is a natural, orally bioavailable compound derived from glucobrassicanin. It functions as an inhibitor of NF-κB signaling by blocking IκBα kinase activation. This small molecule is widely used in research areas such as cancer, inflammation, and immunology for both in vitro and in vivo experimental studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 700-06-1
• MW: 147.17
• Purity: 100.00%
• Formula: C₉H₉NO
• SMILES: C(O)C=1C=2C(NC1)=CC=CC2
• Target: NF-κB,Endogenous Metabolite,Aryl Hydrocarbon Receptor,p53,E1/E2/E3 Enzyme
• Solubility: DMSO:1.61 mg/mL (10.94 mM);Ethanol:28 mg/mL (190.26 mM);H2O:7 mg/mL (47.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.79 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, I3C, EndogenousMetabolite, Indole 3 carbinol, Indole3carbinol, Indole-3-carbinol, Indole-3-Methanol, inhibit, p53, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, NFκB, NFkB, NF-kB, 3-Indolemethanol, AhR, ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, E1 activating enzyme, E1 Enzyme, E2 Enzyme, E2 conjugating enzyme, E1Enzyme, E1/E2/E3 Enzyme, Endogenous Metabolite, E3 ligating enzyme, E3Enzyme, E3 Enzyme, E2Enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase, Ubiquitin activating enzyme

Compound Identifiers

PubChem CID

3712