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Indole-2-carboxylic acid

SKU: orb3170262

Description

Indole-2-carboxylic acid is an indole carboxylic acid compound with multi-target biological activity, exhibiting neuroprotective, antiviral, and antioxidant properties. Indole-2-carboxylic acid is a competitive antagonist at the glycine site of the NMDA receptor (Ki = 15 μM). Indole-2-carboxylic acid specifically inhibits the potentiating effect of glycine on NMDA-gated currents, blocking the neurotoxicity caused by excessive NMDA receptor activation, and can be used in research on the treatment of neurodegenerative diseases and cerebral ischemic injury. Indole-2-carboxylic acid is also an HIV-1 integrase inhibitor; it interferes with the integration of viral DNA into the host genome and can be used in the development of anti-HIV drugs.

Research Area

Infectious Disease & Virology, Neuroscience, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1477-50-5
MW161.1574
Purity99.79% (May vary between batches)
FormulaC9H7NO2
SMILESOC(=O)C1=CC2=C(N1)C=CC=C2
TargetNMDAR,HIV Protease

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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10 g
$ 70.00
25 g
$ 90.00
50 g
$ 110.00
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