Indisulam

SKU: orb1225992

Description

Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines; causes blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E, shows activity in multiple tumor types, most prominently in colon and lung cancer.Breast Cancer Phase 2 Discontinued(In Vitro):Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death.(In Vivo):Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models.

Key Properties

• CAS Number: 165668-41-7
• MW: 385.85
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₂ClN₃O₄S₂
• SMILES: O=S(C1=CC=C(S(=O)(N)=O)C=C1)(NC2=CC=CC3=C2NC=C3Cl)=O
• Target: CDK
• Solubility: DMSO: 20mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)

Bioactivity

• In Vivo:
  Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models. Animal model: Female BALB/c nu/nu mice aged 7 weeks (HCT116 colon, LX-1 lung, SW620 colon, HCT115 colon, PC-9 lung, DLD-1 colon and WiDr colon models). Dosage: 12.5, 25, 50 (100) mg/kg. Administration: IV daily for 4 days. Result: Exhibited anti-tumor activity.
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• In Vitro:
  Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death. Cell Cycle Analysis Cell line: P388 murine leukaemia cells. Concentration: 0-50 μg/mL. Incubation time: 12-48 h. Result: Accumulated P388 cells in the G1 phase.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E 7070 | E7070

Quick Database Links

Gene Symbol

CDK