Indibulin

SKU: orb1308196

Description

Indibulin

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 204205-90-3
• MW: 389.83
• Purity: 99.83% (May vary between batches)
• Formula: C₂₂H₁₆ClN₃O₂
• SMILES: Clc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1
• Target: Apoptosis,Chk,Microtubule Associated
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (6.41 mM);DMSO:50 mg/mL (128.26 mM)

Bioactivity

• In Vitro:
  Indibulin, a synthetic inhibitor of tubulin assembly, has shown promising anticancer activity. Using time-lapse confocal microscopy, indibulin dampens the dynamic instability of individual microtubules in live breast cancer cells. Indibulin treatment also perturbed the localization of end-binding proteins at the growing microtubule ends in MCF-7 cells. Indibulin reduced inter-kinetochoric tension, produced aberrant spindles, activated mitotic checkpoint proteins Mad2 and BubR1, and induced mitotic arrest in MCF-7 cells. Indibulin-treated MCF-7 cells underwent apoptosis-mediated cell death. Further, the combination of indibulin with an anticancer drug vinblastine was found to exert synergistic cytotoxic effects on MCF-7 cells. Interestingly, indibulin displayed a stronger effect on the undifferentiated neuroblastoma (SH-SY5Y) cells than the differentiated neuronal cells. Unlike indibulin, vinblastine and colchicine produced similar depolymerizing effects on microtubules in both differentiated and undifferentiated SH-SY5Y cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D 24851, D24851, D-24851, Apoptosis, Inhibitor, Indibulin, inhibit, Microtubule/Tubulin, MicrotubuleAssociated, Microtubule Associated, ZIO 301, ZIO301, ZIO-301, Tubulin

Compound Identifiers

PubChem CID

2929