Incensole acetate

SKU: orb1684525

Description

Incensole acetate is a natural TRPV3 channel agonist that triggers calcium influx in TRPV3-expressing HEK293 cells. It demonstrates anxiolytic and anti-inflammatory activities in vivo, modulating brain c-Fos expression, making it a valuable research tool for neuroinflammation and behavioral studies.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 34701-53-6
• MW: 348.52
• Purity: 98.32% (May vary between batches)
• Formula: C₂₂H₃₆O₃
• SMILES: CC(C)[C@@]12CC[C@@](C)(O1)[C@H](CC\C(C)=C\CC\C(C)=C\C2)OC(C)=O
• Target: MMP,Immunology/Inflammation related,TRP/TRPV Channel,Apoptosis
• Solubility: DMSO:80 mg/mL (229.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.47 mM)

Bioactivity

• Target IC50:
  HEK293 cells:2.2 μM
• In Vitro:
  Methods: To investigate the preventive effects on Aβ25-35-induced neurotoxicity in homo sapiens olfactory bulb neural stem cells (hOBNSCs), hOBNSCs were pretreated with Incensole acetate (100 μM) for 4 hours prior to Aβ25-35 treatment. Cell viability was assessed using the MTT assay. Results: Aβ25-35 significantly reduced cell viability, whereas Incensole acetate pretreatment markedly restored cell viability.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NFkB

Compound Identifiers

PubChem CID

53386731