INCB159020

SKU: orb2945847

Description

INCB159020 is a potent and orally bioavailable small molecule inhibitor selectively targeting the KRAS G12D mutant, with a binding affinity (SPR) of 2.2 nM. It has demonstrated anti-tumor efficacy in preclinical in vitro and in vivo studies, supporting its use in oncology research focused on RAS-driven cancers.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2923669-20-7
• MW: 664.171
• Formula: C₃₇H₃₅ClFN₇O₂
• SMILES: [C@@H](C)(C=1N(C2=C(C(=NC=3C2=CC(CCC#N)=C(C3F)C4=C(C)C(Cl)=CC=C4)C=5C=NC(C)=CN5)C1)[C@H]6[C@@]7(C[C@]6(NC7)[H])[H])N8C(=O)COCC8
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168226157