INCB126503

SKU: orb3135550

Description

INCB126503 is an orally active and selective inhibitor of FGFR2/3, with IC50 values of 70 nM for FGFR1, 2.1 nM for FGFR2, 1.2 nM for FGFR3, 0.92 nM for FGFR3-V555L, 0.85 nM for FGFR3-V555M, and 64 nM for FGFR4. This compound inhibits FGFR signaling in vivo without causing hyperphosphatemia and demonstrates antitumor efficacy in xenograft models with FGFR3 genetic alterations.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2640089-88-7
• MW: 470.57
• Formula: C₂₇H₃₀N₆O₂
• SMILES: O(C)C=1C=C2C(C(=NN2)C=3C=CC(=NC3)N4C[C@]5(N(CC4)C[C@H](O)C5)[H])=NC1C6=C(C)C(C)=CC=C6
• Target: FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FGFR