INCA-6

SKU: orb1704962

Description

INCA-6 is a cell-permeable, small-molecule inhibitor that selectively disrupts the calcineurin-NFAT signaling pathway by blocking the phosphatase site. It is utilized in both in vitro and in vivo research to study immune response, T-cell activation, and cardiac hypertrophy.

Key Properties

• CAS Number: 3519-82-2
• MW: 284.31
• Purity: 99.88% (May vary between batches)
• Formula: C₂₀H₁₂O₂
• SMILES: O=C1C=CC(=O)C2=C1C1c3ccccc3C2c2ccccc12
• Target: Others
• Solubility: DMSO:2.85 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner.
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• In Vitro:
  In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, INCA 6, INCA6, INCA-6, Nuclear factor of activated Tcells (NFAT), oxygen-induced, NFAT, neovascularization, microvascular, factors, endothelial, Inhibitor, transcription, Triptycene-1,4-quinone, retinal, retinopathy

Compound Identifiers

PubChem CID

230748