Inavolisib

SKU: orb1308276

Description

Inavolisib

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2060571-02-8
• MW: 407.37
• Purity: 99.96% (May vary between batches)
• Formula: C₁₈H₁₉F₂N₅O₄
• SMILES: C[C@H](Nc1ccc2-c3nc(cn3CCOc2c1)N1[C@@H](COC1=O)C(F)F)C(N)=O
• Target: Apoptosis,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (24.55 mM);DMSO:240 mg/mL (589.15 mM)

Bioactivity

• Target IC50:
  HCC1954 cells:60 nM|MCF-7 cells:30 nM|PI3Kα:0.038 nM
• In Vivo:
  METHODS: p110a protein depletion was studied in a p110a mutant xenograft breast cancer model using Inavolisib (GDC-0077) at a single oral dose of 50 mg/kgDC-0077. RESULTS Inavolisib (GDC-0077) depleted p110a protein expression for up to 8 hours.
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• In Vitro:
  METHODS: Cell viability was assayed using Inavolisib (GDC-00777) up to 100 μmol/L in a panel of cancer cell lines. RESULTS Inavolisib (GDC-00777) is a stronger cellular antiproliferative inducer.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RG 6114, RG6114, RG-6114, Phosphoinositide 3-kinase, PI3K, PI3Kα, Inhibitor, GDC 0077, GDC0077, GDC-0077, inhibit, Inavolisib, Apoptosis

Compound Identifiers

PubChem CID

124173720