Inauhzin

SKU: orb1307263

Description

Inauhzin is a novel SIRT1 inhibitor that reactivates p53, inducing p53-dependent apoptosis in human cancer cells like A549 (IC50=3 µM) without significant genotoxicity. It serves as a valuable chemical probe for researching p53 biology, cancer mechanisms, and apoptosis in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 309271-94-1
• MW: 469.58
• Purity: 99.36% (May vary between batches)
• Formula: C₂₅H₁₉N₅OS₂
• SMILES: CCC(Sc1nnc2c(n1)[nH]c1ccccc21)C(=O)N1c2ccccc2Sc2ccccc12
• Target: Sirtuin,MDM-2/p53
• Solubility: DMSO:45 mg/mL (95.83 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.26 mM)

Bioactivity

• Target IC50:
  SIRT1:3 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sirtuin, SIRT1, Inauhzin, INZ, Inhibitor, inhibit, MDM-2/p53

Compound Identifiers

PubChem CID

5494506