Inarigivir soproxil

SKU: orb1308199

Description

Inarigivir soproxil (SB9200) is an innate immunity agonist with antiviral activity. It demonstrates efficacy against resistant hepatitis C virus variants, showing EC50 values of 2.2 and 1.0 μM in genotype 1 replicon assays. Its research applications include studying host-directed antiviral mechanisms in both cellular and animal models of viral infection.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 942123-43-5
• MW: 703.62
• Purity: 98.44% (May vary between batches)
• Formula: C₂₅H₃₄N₇O₁₃PS
• SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1OP(OC[C@H]2O[C@H](C[C@@H]2O)N3C=4C(N=C3)=C(N)N=CN4)(SCOC(OC(C)C)=O)=O)N5C(=O)NC(=O)C=C5
• Target: HCV Protease,HBV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.68 mM);DMSO:102 mg/mL (144.96 mM)

Bioactivity

• Target IC50:
  HCV 1a/1b:(EC50)2.2/1.0 μM
• In Vitro:
  Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB9200, SB-9200, SB 9200, antiviral activity against, HCVProtease, HCV Protease, HCV replicon, HCV 1a/1b, HCV, HBV, Hepatitis C virus, Hepatitis B virus, innate immunity, GS 9992, GS9992, GS-9992, inhibit, Inarigivir soproxil, Inhibitor

Compound Identifiers

PubChem CID

24737742