Inarigivir ammonium

SKU: orb1298048

Description

Inarigivir ammonium (SB-9200) is a dinucleotide RIG-I agonist that activates innate immunity to combat hepatitis B virus. It has demonstrated antiviral efficacy in reducing HBV DNA in transgenic mouse models and has been investigated in vitro for its immunostimulatory mechanisms against viral infections.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2172788-92-8
• MW: 604.53
• Purity: 99.91% (May vary between batches)
• Formula: C₂₀H₂₉N₈O₁₀PS
• SMILES: NC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1.N
• Target: HBV
• Solubility: DMSO:98 mg/mL (162.11 mM)

Bioactivity

• In Vivo:
  Administration of 100 mg/kg/day Inarigivir (ip) significantly reduces viral DNA in the liver and shows anti-HBV activity while serum HBV DNA is not reduced. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values.
• In Vitro:
  Inarigivir exhibits activity against HBV (hepatitis B virus) variants, including those resistant to all approved nucleo(s)tide analogues for chronic hepatitis B treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ORI 9020, ORI9020, ORI-9020, ORI-9020 ammonium, SB 9000, SB9000, SB-9000, SB-9200 ammonium, RIG-I, antiviral, Hepatitis B virus, HCV, HBV, Inhibitor, Huh7, inhibit, Inarigivir, Inarigivir ammonium

Compound Identifiers

PubChem CID

162623408